Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations meta-analysis Meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 SyndromeArticle Published on 2022-09-302022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] antibody Blood CCR5 Cell clinical COVID exploratory immune Immunosuppression Leronlimab Level Long long COVID. mechanism normalized placebo-treated participants Registration Responder significantly increased surface symptomatic treated Trial [DOI] 10.1093/cid/ciac226 PMC 바로가기
Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2인간 유전자 TMPRSS2 및 CCR5의 대립형질 변이와 SARS-CoV-2에 의한 바이러스 감염에 대한 내성Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] addition age allelic variant allelic variants analyzed CCR5 CCR5 gene Clinical course close contact Comorbidities Comorbidity conditions contact with correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 infection demonstrated described determinant Disease progression disease severity Europe explain First wave Gender Genetic polymorphism genetic variability highest Human human genes human populations identify Italy life cycle male mortality rate mortality rates old age performed polymorphism predisposition progression resistance rs12329760 rs333 rs35074065. SARS-CoV-2 SARS-CoV-2 first wave infection SARS-COV-2 infection SARS-CoV-2 viral Sicily subject subjects TMPRSS2 TMPRSS2 gene viral infection virus virus infection with COVID-19 [DOI] 10.3390/ijms23169171 PMC 바로가기 [Article Type] Article
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literatureReview article Published on 2022-08-012022-10-05 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE addition affecting age article association CCR5 cellular protease Clinical outcome Comorbidities correlation COVID-19 COVID-19 severity Deletion evaluate expression finding Genetic Genetic predisposition genetic risk genetic susceptibility genetics help HLA haplotypes host genetics IFNs IFNλ immune system individual Mortality mutations polymorphism Polymorphisms Proteins reduced retrieved risk risk factor SARS-CoV-2 several gene severity severity of COVID-19 smoking susceptibility systematic review TLR TMPRSS2 TNF Treatment upregulation vaccination Variability with COVID-19 [DOI] 10.1016/j.gene.2022.146674 [Article Type] Review article
Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis
Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19COVID-19 치료에 이중 케모카인 수용체 CCR2/CCR5 억제제 세니크리비록을 사용하는 이유Review Published on 2022-06-242022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus addition agent anti-inflammatory action anti-inflammatory actions attenuate caused CCR2 CCR5 Cenicriviroc Chemokine receptor clinical Clinical course clinical trial clinical trials Combination complications coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Dexamethasone fibrosis global pandemic IMPROVE infecting Inflammation inhibitor investigational agent late stage NASH nonalcoholic steatohepatitis Organ failure outcome outcomes pathway Pathways patients with COVID-19 patients with HIV Prevent rationale reduce respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Standard of care steatohepatitis the disease Treatment Trial [DOI] 10.1371/journal.ppat.1010547 PMC 바로가기 [Article Type] Review
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19 Research Published on 2022-03-222022-10-05 Journal: NPJ Genomic Medicine [Category] 바이오마커, 신약개발, 유전자 메커니즘, [키워드] Analysis application applied approach approach average CCR5 CCR9 complications Concentration COVID-19 COVID-19 severity CXCR6 disease expression Genes Gustatory higher risk host genetics Immunity implication individual Inflammatory locus methodology molecular mechanism much higher olfactory phenotype severe COVID-19 severe disease severity SLC6A20 traits transcriptomic [DOI] 10.1038/s41525-022-00296-y [Article Type] Research
The major genetic risk factor for severe COVID-19 is associated with protection against HIV심각한 COVID-19의 주요 유전적 위험 요소는 HIV에 대한 보호와 관련이 있습니다Article Published on 2022-03-012022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] carrier carriers CCR5 chemokine receptors chromosome chromosome 3 COVID-19 DNA down-regulated expression genetic risk factor genetic risk factors genetics Genetics. Haplotype HIV HIV infection initiative lower risk modulate Nature outcome risk severe COVID-19 variant [DOI] 10.1073/pnas.2116435119 PMC 바로가기 [Article Type] Article